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| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Denis Istomin | Win | 6-4, 6-0 |
| Third Round | Kevin Anderson | Win | 7-5, 6-2 |
| Quarterfinals | Novak Djokovic | Win | 2-6, 7-5, 6-4 |
| Semifinals | Rafael Nadal | Loss | 2-6, 4-6 |
| Mutua Madrid Open | ||
| Surface: Clay | Date: May 4 - May 12 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jerzy Janowicz | Win | 6-7 (3-7), 6-3, 6-2 |
| Third Round | Kevin Anderson | Win | 7-6 (7-5), 7-5 |
| Quarterfinals | Andy Murray | Win | 7-6 (7-3), 6-4 |
| Semifinals | Stanislas Wawrinka | Loss | 3-6, 6-4, 4-6 |
| Open Banco Sabadell | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nikolay Davydenko | Win | 3-6, 7-5, 6-4 |
| Third Round | Tommy Robredo | Loss | 6-3, 6-7 (5-7), 3-6 |
| Tennis Masters Monte-Carlo | ||
| Surface: Clay | Date: Apr. 14 - Apr. 21 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marcel Granollers | Win | 7-5, 6-4 |
| Third Round | Fabio Fognini | Loss | 4-6, 2-6 |
| Miami Masters | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daniel Gimeno-Traver | Win | 5-7, 7-6 (7-3), 6-2 |
| Third Round | Alejandro Falla | Win | 2-6, 7-6 (8-6), 6-4 |
| Fourth Round | Sam Querrey | Win | 6-1, 6-1 |
| Quarterfinals | Richard Gasquet | Loss | 3-6, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mischa Zverev | Win | 6-2, 6-4 |
| Third Round | Florian Mayer | Win | 6-4, 6-1 |
| Fourth Round | Richard Gasquet | Win | 6-1, 7-5 |
| Quarterfinals | Kevin Anderson | Win | 6-4, 6-4 |
| Semifinals | Rafael Nadal | Loss | 4-6, 5-7 |
| Dubai Tennis Championships | ||
| Surface: Hard | Date: Feb. 25 - Mar. 2 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Rajeev Ram | Win | 6-1, 6-3 |
| Second Round | Tobias Kamke | Win | 7-5, 6-1 |
| Quarterfinals | Dmitry Tursunov | Win | 6-3, 6-2 |
| Semifinals | Roger Federer | Win | 3-6, 7-6 (10-8), 6-4 |
| Final | Novak Djokovic | Loss | 5-7, 3-6 |
| Open 13 | ||
| Surface: Hard | Date: Feb. 18 - Feb. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ernests Gulbis | Win | 6-4, 6-7 (10-12), 6-4 |
| Quarterfinals | Jerzy Janowicz | Win | 6-3, 6-7 (0-7), 6-3 |
| Semifinals | Dmitry Tursunov | Win | 6-2, 6-1 |
| Final | Jo-Wilfried Tsonga | Loss | 6-3, 6-7 (6-8), 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 13 - Jan. 27 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Michael Russell | Win | 6-3, 7-5, 6-3 |
| Second Round | Guillaume Rufin | Win | 6-2, 6-2, 6-4 |
| Third Round | Jurgen Melzer | Win | 6-3, 6-2, 6-2 |
| Fourth Round | Kevin Anderson | Win | 6-3, 6-2, 7-6 (15-13) |
| Quarterfinals | Novak Djokovic | Loss | 1-6, 6-4, 1-6, 4-6 |
| Chennai Open | ||
| Surface: Hard | Date: Dec. 30 - Jan. 6 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Somdev Devvarman | Win | 6-3, 6-1 |
| Quarterfinals | Roberto Bautista-Agut | Loss | 5-7, 6-2, 3-6 |
